Dopamine and hippocampal synaptic plasticity
نویسندگان
چکیده
منابع مشابه
Synaptic plasticity: hippocampal LTP.
One of the most intensively studied forms of synaptic plasticity is long-term potentiation (LTP). The past year has seen further evidence advanced on both sides of the presynaptic/postsynaptic locus of expression debate, without an obvious path to reconcile the two views. Real progress has been made, however, in clarifying the possible role of nitric oxide as a retrograde messenger and the cell...
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The effect of ketamine (1-100 µM), which has NMDA receptor antagonist properties, on synaptic transmission and long-term potentiation (LTP) in CAl area of rat hippocampus was examined in vitro. Field potentials were recorded in pyramidal cell layer following Schaffer collateral stimulation. Primed-burst stimulation (PEs) was used for induction of LTP. The amplitude of population spiks (PS) was ...
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The dependence of NMDA receptor-dependent LTP on postsynaptic depolarization and increases in postsynaptic calcium, coupled with evidence supporting presynaptically mediated increases in transmitter release accompanying LTP, suggest that a retrograde transsynaptic messenger participates in the synaptic enhancement. Although many questions remain unanswered, the available evidence suggests a rol...
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ژورنال
عنوان ژورنال: Procedia Computer Science
سال: 2020
ISSN: 1877-0509
DOI: 10.1016/j.procs.2020.02.186